Halpern Lab

Center for EPR Imaging in Vivo Physiology

Research Goals

In collaboration with researchers at the Unviersity of Denver and the University of Maryland, the Center for Electron Paramagnetic Resonance (EPR) Imaging in Vivo Physiology aims to create new imaging technologies in order to better visualize the tissues of living animals.  The EPR imaging technology under development by the Center has powerful implications for the treatment of cancers, strokes, peripheral vascular diseases and heart attacks.


The Center receives funding from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), a part of the National Institutes of Health (NIH), as a Technology Development Resource. The Center assists other NIH-funded researchers with attaining the latest technology in the field of EPR imaging.

Recent Publications

From the Center's research in collaboration with the University of Denver and the University of Maryland, several peer-reviewed journal articles have been published. For a full list of publications, see the Center's website. In addition to these articles, the research team has registered several US patents for their innovations.

  • Elas M, Ichikawa K and Halpern HJ, Oxidative Stress Imaging in Live Animals with Techniques Based on Electron Paramagnetic Resonance. Radiat Res. 2012. PubMed.
  • Mitchell DG, Quine RW, Tseitlin M, Eaton SS and Eaton GR, X-band rapid-scan EPR of nitroxyl radicals. J Magn Reson. 2012. 214(1):221-6. PubMed.
  • Tormyshev VM, Genaev AM, Sal'nikov GE, Rogozhnikova OY, Troitskaya TI, Trukhin DV, Mamatyuk VI, Fadeev DS and Halpern HJ, Triarylmethanols with Bulky Aryl Groups and the NOESY/EXSY Experimental Observation of a Two-Ring-Flip Mechanism for the Helicity Reversal of Molecular Propeller. Euro. J Organic Chem. 2012. 2012( 3) 623–629
  • Tseitlin M, Quine RW, Eaton SS and Eaton GR, Use of polyphase continuous excitation based on the Frank sequence in EPR. J Magn Reson. 2011. 211(2):221-7. PubMed.
  • Biller JR, Meyer V, Elajaili H, Rosen GM, Kao JP, Eaton SS and Eaton GR, Relaxation times and line widths of isotopically-substituted nitroxides in aqueous solution at X-band. J Magn Reson. 2011. 212(2):370-7. PubMed.