People

Ralph R. Weichselbaum, MD

  • Chair of Radiation and Cellular Oncology
    Daniel K. Ludwig Distinguished Service Professor of Radiation and Cellular Oncology
    Committee on Cancer Biology
    Committee on Clinical Pharmacology and Pharmacogenomics
  • Websites: Research Network Profile
  • Contact: rrw@radonc.uchicago.edu
  • Graduate Program: Cancer Biology

University of Illinois
Chicago IL
MD - Medicine
1971

University of Wisconsin
Madison WI
BS - Liberal Arts
1967

Methodological Development of Combination Drug and Radiation Therapy in Basic and Clinical Research.
Chargari C, Levy A, Paoletti X, Soria JC, Massard C, Weichselbaum RR, Deutsch E. Methodological Development of Combination Drug and Radiation Therapy in Basic and Clinical Research. Clin Cancer Res. 2020 May 14.
PMID: 32409306

Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable.
Kirsch DG, Diehn M, Cucinoata FA, Weichselbaum R. Lack of supporting data make the risks of a clinical trial of radiation therapy as a treatment for COVID-19 pneumonia unacceptable. Radiother Oncol. 2020 May 12.
PMID: 32413531

Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.
Kim SM, DeFazio JR, Hyoju SK, Sangani K, Keskey R, Krezalek MA, Khodarev NN, Sangwan N, Christley S, Harris KG, Malik A, Zaborin A, Bouziat R, Ranoa DR, Wiegerinck M, Ernest JD, Shakhsheer BA, Fleming ID, Weichselbaum RR, Antonopoulos DA, Gilbert JA, Barreiro LB, Zaborina O, Jabri B, Alverdy JC. Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity. Nat Commun. 2020 May 11; 11(1):2354.
PMID: 32393794

Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling.
Shi Y, Zheng W, Yang K, Harris KG, Ni K, Xue L, Lin W, Chang EB, Weichselbaum RR, Fu YX. Intratumoral accumulation of gut microbiota facilitates CD47-based immunotherapy via STING signaling. J Exp Med. 2020 May 04; 217(5).
PMID: 32142585

Cooperation of genes in HPV16 E6/E7-dependent cervico-vaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.
Böttinger P, Schreiber K, Hyjek E, Krausz T, Spiotto MT, Steiner M, Idel C, Booras H, Beck-Engeser G, Riederer J, Willimsky G, Wolf SP, Karrison T, Jensen E, Weichselbaum RR, Nakamura Y, Yew PY, Lambert PF, Kurita T, Kiyotani K, Leisegang M, Schreiber H. Cooperation of genes in HPV16 E6/E7-dependent cervico-vaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens. Carcinogenesis. 2020 Mar 28.
PMID: 32221533

DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy.
Szymura SJ, Bernal GM, Wu L, Zhang Z, Crawley CD, Voce DJ, Campbell PA, Ranoa DE, Weichselbaum RR, Yamini B. DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-?B and sensitize to alkylating chemotherapy. BMC Biol. 2020 03 24; 18(1):32.
PMID: 32209106

A Phase I trial assessing the safety and tolerability of a therapeutic DNA vaccination against HPV16 and HPV18 E6/E7 oncogenes after chemoradiation for cervical cancer.
Hasan Y, Furtado L, Tergas A, Lee N, Brooks R, McCall A, Golden D, Jolly S, Fleming G, Morrow M, Kraynyak K, Sylvester A, Arif F, Levin M, Schwartz D, Boyer J, Skolnik J, Esser M, Kumar R, Bagarazzi M, Weichselbaum R, Spiotto M. A Phase I trial assessing the safety and tolerability of a therapeutic DNA vaccination against HPV16 and HPV18 E6/E7 oncogenes after chemoradiation for cervical cancer. Int J Radiat Oncol Biol Phys. 2020 Mar 06.
PMID: 32151670

Definition, Biology, and History of Oligometastatic and Oligoprogressive Disease.
Foster CC, Pitroda SP, Weichselbaum RR. Definition, Biology, and History of Oligometastatic and Oligoprogressive Disease. Cancer J. 2020 Mar/Apr; 26(2):96-99.
PMID: 32205532

Radiotherapy and Immunotherapy for Cancer: From "Systemic" to "Multisite".
Arina A, Gutiontov SI, Weichselbaum RR. Radiotherapy and Immunotherapy for Cancer: From "Systemic" to "Multisite". Clin Cancer Res. 2020 Feb 11.
PMID: 32047000

Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis.
Liauw SL, Ham SA, Das LC, Rudra S, Packiam V, Koshy M, Weichselbaum RR, Becker YT, Bodzin A, Eggener SE. Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis. J Natl Cancer Inst. 2019 Nov 15.
PMID: 31728517

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