University of Illinois
Chicago IL
MD - Medicine
1971University of Wisconsin
Madison WI
BS - Liberal Arts
1967Bifunctional Metal-Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio-Immunotherapy.
Bifunctional Metal-Organic Framework Synergistically Enhances Radiotherapy and Activates STING for Potent Cancer Radio-Immunotherapy. Angew Chem Int Ed Engl. 2024 Oct 07; e202417027.
PMID: 39375150Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment.
Multifunctional Nanomaterials Mediate Cholesterol Depletion for Cancer Treatment. Angew Chem Int Ed Engl. 2024 Nov 11; 63(46):e202412844.
PMID: 39146242Two decades of advances in clinical oncology - lessons learned and future directions.
Two decades of advances in clinical oncology - lessons learned and future directions. Nat Rev Clin Oncol. 2024 Nov; 21(11):771-780.
PMID: 39354161Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance.
Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance. Clin Cancer Res. 2024 Oct 01; 30(19):4450-4463.
PMID: 38691100YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production.
YTHDF1 loss in dendritic cells potentiates radiation-induced antitumor immunity via STING-dependent type I IFN production. J Clin Invest. 2024 Sep 26.
PMID: 39325547Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis.
Digitonin-Loaded Nanoscale Metal-Organic Framework for Mitochondria-Targeted Radiotherapy-Radiodynamic Therapy and Disulfidptosis. Adv Mater. 2024 Sep 10; e2405494.
PMID: 39252688Radiotherapy, immunity, and immune checkpoint inhibitors.
Radiotherapy, immunity, and immune checkpoint inhibitors. Lancet Oncol. 2024 Aug; 25(8):e352-e362.
PMID: 39089313Sharing the Burden: The Case for Definitive Local Therapy in Place of Immune Checkpoint Blockade for Patients With a Low-Volume Burden of Metastatic Disease.
Sharing the Burden: The Case for Definitive Local Therapy in Place of Immune Checkpoint Blockade for Patients With a Low-Volume Burden of Metastatic Disease. J Clin Oncol. 2024 Oct 10; 42(29):3387-3391.
PMID: 39038267STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition. Sci Adv. 2024 Jul 19; 10(29):eado0082.
PMID: 39018400Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy.
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Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy. Adv Sci (Weinh). 2024 Sep; 11(35):e2403520.
PMID: 39013093
People
Ralph R. Weichselbaum, MD
-
Chair of Radiation and Cellular Oncology
Daniel K. Ludwig Distinguished Service Professor of Radiation and Cellular Oncology
Committee on Cancer Biology - Websites: Research Network Profile
- Contact: rrweichs@uchicago.edu
- Graduate Programs: Cancer Biology, UChicago Biosciences