People

Ralph R. Weichselbaum

University of Illinois
Chicago IL
MD - Medicine
1971

University of Wisconsin
Madison WI
BS - Liberal Arts
1967

STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition. Sci Adv. 2024 Jul 19; 10(29):eado0082.
PMID: 39018400

Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy.
Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy. Adv Sci (Weinh). 2024 Jul 16; e2403520.
PMID: 39013093

Simultaneous Protonation and Metalation of a Porphyrin Covalent Organic Framework Enhance Photodynamic Therapy.
Simultaneous Protonation and Metalation of a Porphyrin Covalent Organic Framework Enhance Photodynamic Therapy. J Am Chem Soc. 2024 Jun 05.
PMID: 38837955

Radiotherapy and immunology.
Radiotherapy and immunology. J Exp Med. 2024 Jul 01; 221(7).
PMID: 38771260

Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites.
Radiotherapy Enhances Metastasis Through Immune Suppression by Inducing PD-L1 and MDSC in Distal Sites. Clin Cancer Res. 2024 May 01; 30(9):1945-1958.
PMID: 38427437

Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance.
Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance. Clin Cancer Res. 2024 May 01.
PMID: 38691100

Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy.
Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy. Adv Sci (Weinh). 2024 Jun; 11(23):e2310309.
PMID: 38477411

Reconciling the discrepancies in randomized data of combining immunotherapy and radiation therapy: Not all radiotherapy is created equal.
Reconciling the discrepancies in randomized data of combining immunotherapy and radiation therapy: Not all radiotherapy is created equal. Eur J Cancer. 2024 Apr; 201:113972.
PMID: 38430868

Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy.
Immunogenic Bifunctional Nanoparticle Suppresses Programmed Cell Death-Ligand 1 in Cancer and Dendritic Cells to Enhance Adaptive Immunity and Chemo-Immunotherapy. ACS Nano. 2024 Feb 13; 18(6):5152-5166.
PMID: 38286035

Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy.
Nanoscale Covalent Organic Framework with Staggered Stacking of Phthalocyanines for Mitochondria-Targeted Photodynamic Therapy. J Am Chem Soc. 2024 01 10; 146(1):849-857.
PMID: 38134050

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