Howard J. Halpern, MD, PhD, specializes in medical imaging techniques. He is an expert in very low frequency-imaging-electron paramagnetic resonance (VLF-I-EPR). This technique enables measurement of changes in oxygen content in tumor tissues--a key determinant of response to radiation therapy.
Dr. Halpern is the co-author of a textbook on free radical biology. He serves as the principal investigator for the Oversight Committee for the Laboratory Training of Radiation Oncology Residents.
University of Wisconsin
Madison, Wisconsin
PhD - High Energy Physics
1976
University of Miami
Miami, Florida
MD - Medicine
061980
Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.
Bader KB, Wallach EL, Shekhar H, Flores-Guzman F, Halpern HJ, Hernandez SL. Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 08 05; 66(16).
PMID: 34271560
A balanced total-variation-Chambolle-Pock algorithm for EPR imaging.
Qiao Z, Redler G, Epel B, Halpern H. A balanced total-variation-Chambolle-Pock algorithm for EPR imaging. J Magn Reson. 2021 07; 328:107009.
PMID: 34058712
Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.
Gertsenshteyn I, Epel B, Barth E, Leoni L, Markiewicz E, Tsai HM, Fan X, Giurcanu M, Bodero D, Zamora M, Sundramoorthy S, Kim H, Freifelder R, Bhuiyan M, Kucharski A, Karczmar G, Kao CM, Halpern H, Chen CT. Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images. Radiol Imaging Cancer. 2021 03; 3(2):e200104.
PMID: 33817651
Development of a PET/EPRI combined imaging system for assessing tumor hypoxia.
Kim H, Epel B, Sundramoorthy S, Tsai HM, Barth E, Gertsenshteyn I, Halpern H, Hua Y, Xie Q, Chen CT, Kao CM. Development of a PET/EPRI combined imaging system for assessing tumor hypoxia. J Instrum. 2021 Mar; 16(3).
PMID: 33868448
Small Animal IMRT Using 3D-Printed Compensators.
Redler G, Pearson E, Liu X, Gertsenshteyn I, Epel B, Pelizzari C, Aydogan B, Weichselbaum R, Halpern HJ, Wiersma RD. Small Animal IMRT Using 3D-Printed Compensators. Int J Radiat Oncol Biol Phys. 2021 06 01; 110(2):551-565.
PMID: 33373659
Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance.
Halpern HJ, Epel BM. Going Low in a World Going High: The Physiologic Use of Lower Frequency Electron Paramagnetic Resonance. Appl Magn Reson. 2020 Oct; 51(9-10):887-907.
PMID: 33776216
Predictors of pressure injury development in critically ill adults: A retrospective cohort study.
Sala JJ, Mayampurath A, Solmos S, Vonderheid SC, Banas M, D'Souza A, LaFond C. Predictors of pressure injury development in critically ill adults: A retrospective cohort study. Intensive Crit Care Nurs. 2021 Feb; 62:102924.
PMID: 12768596
How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen-dependent pathologies.
Swartz HM, Flood AB, Schaner PE, Halpern H, Williams BB, Pogue BW, Gallez B, Vaupel P. How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen-dependent pathologies. Physiol Rep. 2020 08; 8(15):e14541.
PMID: 32786045
Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue.
Gertsenshteyn I, Giurcanu M, Vaupel P, Halpern H. Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue. J Physiol. 2021 03; 599(6):1759-1767.
PMID: 32506448
The clinical utility of imaging methods used to measure hypoxia in cervical cancer.
Waller J, Onderdonk B, Flood A, Swartz H, Shah J, Shah A, Aydogan B, Halpern H, Hasan Y. The clinical utility of imaging methods used to measure hypoxia in cervical cancer. Br J Radiol. 2020 Jul; 93(1111):20190640.
PMID: 32286849