Howard J. Halpern, MD, PhD, specializes in medical imaging techniques. He is an expert in very low frequency-imaging-electron paramagnetic resonance (VLF-I-EPR). This technique enables measurement of changes in oxygen content in tumor tissues--a key determinant of response to radiation therapy.
Dr. Halpern is the co-author of a textbook on free radical biology. He serves as the principal investigator for the Oversight Committee for the Laboratory Training of Radiation Oncology Residents.
University of Wisconsin
Madison, Wisconsin
PhD - High Energy Physics
1976University of Miami
Miami, Florida
MD - Medicine
061980Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance.
Tumor Hypoxia Assessment: In Vivo 3D Oxygen Imaging Through Electron Paramagnetic Resonance. J Vis Exp. 2025 Feb 14; (216).
PMID: 40029823Directional TV algorithm for image reconstruction from sparse-view projections in EPR imaging.
Directional TV algorithm for image reconstruction from sparse-view projections in EPR imaging. Phys Med Biol. 2024 May 30; 69(11).
PMID: 38729205Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner.
Validation of the design of a high-sensitivity and high-resolution PET system for a preclinical PET/EPR hybrid scanner. Nucl Instrum Methods Phys Res A. 2024 Jun; 1063.
PMID: 38736647Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance.
Sensing and Imaging Molecular Oxygen in Mammals with Spin Lattice Relaxation Electron Paramagnetic Resonance. Mol Imaging Biol. 2024 Jun; 26(3):373-381.
PMID: 38548994Accurate reconstruction of 4D spectral-spatial images from sparse-view data in continuous-wave EPRI.
Accurate reconstruction of 4D spectral-spatial images from sparse-view data in continuous-wave EPRI. J Magn Reson. 2024 Apr; 361:107654.
PMID: 38492546Directional TV algorithm for fast EPR imaging.
Directional TV algorithm for fast EPR imaging. J Magn Reson. 2024 Apr; 361:107652.
PMID: 38457937A fully linearized ADMM algorithm for optimization based image reconstruction.
A fully linearized ADMM algorithm for optimization based image reconstruction. J Xray Sci Technol. 2024; 32(6):1481-1504.
PMID: 39704746Corrigendum: Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models.
Corrigendum: Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models. Front Med (Lausanne). 2023; 10:1339872.
PMID: 38116039Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models.
Absolute oxygen-guided radiation therapy improves tumor control in three preclinical tumor models. Front Med (Lausanne). 2023; 10:1269689.
PMID: 37904839A Preclinical Positron Emission Tomography (PET) and Electron-Paramagnetic-Resonance-Imaging (EPRI) Hybrid System: PET Detector Module.
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A Preclinical Positron Emission Tomography (PET) and Electron-Paramagnetic-Resonance-Imaging (EPRI) Hybrid System: PET Detector Module. IEEE Trans Radiat Plasma Med Sci. 2023 Nov; 7(8):794-801.
PMID: 37981977