People

David Grdina, PhD

  • Professor of Radiation and Cellular Oncology
    Committee on Medical Physics
  • Research and Scholarly Interests: Adaptive Responses, Genomic Instability, Radioprotectors, Amifostine, Radiation Biology
  • Websites: Research Network Profile
  • Contact: dgrdina@uchicago.edu
  • Graduate Program: Medical Physics

My research has focused on the development of radio-protective drugs for use in the prevention of radiation-induced genomic instability and subsequent processes leading to cancer development. Specifically, studies are directed at very low dose radiation and select phosphorothioate drug exposures to induce adaptive responses affecting genomic instability development.

University of Houston
Houston TX
MBA - Finance
1980

University of Kansas
Lawrence KS
PhD - Radiation Biophysics
1971

University of Kansas
Lawrence KS
MS - Radiation Biophysics
1969

St. Mary's College
Winona MN
BA - Biology
1966

ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response.
Murley JS, Arbiser JL, Weichselbaum RR, Grdina DJ. ROS modifiers and NOX4 affect the expression of the survivin-associated radio-adaptive response. Free Radic Biol Med. 2018 08 01; 123:39-52.
PMID: 29660403

TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response.
Murley JS, Miller RC, Weichselbaum RR, Grdina DJ. TP53 Mutational Status and ROS Effect the Expression of the Survivin-Associated Radio-Adaptive Response. Radiat Res. 2017 11; 188(5):579-590.
PMID: 28813624

Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells.
Nantajit D, Jetawattana S, Suriyo T, Grdina DJ, Satayavivad J. Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells. Radiat Res. 2017 07; 188(1):66-74.
PMID: 28492344

Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions.
Murley JS, Miller RC, Senlik RR, Rademaker AW, Grdina DJ. Altered expression of a metformin-mediated radiation response in SA-NH and FSa tumor cells treated under in vitro and in vivo growth conditions. Int J Radiat Biol. 2017 07; 93(7):665-675.
PMID: 28281393

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity.
Miller RC, Murley JS, Rademaker AW, Woloschak GE, Li JJ, Weichselbaum RR, Grdina DJ. Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity. Free Radic Biol Med. 2016 10; 99:110-119.
PMID: 27427516

The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose.
Haley BM, Paunesku T, Grdina DJ, Woloschak GE. The Increase in Animal Mortality Risk following Exposure to Sparsely Ionizing Radiation Is Not Linear Quadratic with Dose. PLoS One. 2015; 10(12):e0140989.
PMID: 26649569

CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair.
Qin L, Fan M, Candas D, Jiang G, Papadopoulos S, Tian L, Woloschak G, Grdina DJ, Li JJ. CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair. Cell Rep. 2015 Dec 15; 13(10):2056-63.
PMID: 26670043

NF?B and Survivin-Mediated Radio-Adaptive Response.
Grdina DJ, Murley JS, Miller RC, Woloschak GE, Li JJ. NF?B and Survivin-Mediated Radio-Adaptive Response. Radiat Res. 2015 Apr; 183(4):391-7.
PMID: 25763931

CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection.
Jin C, Qin L, Shi Y, Candas D, Fan M, Lu CL, Vaughan AT, Shen R, Wu LS, Liu R, Li RF, Murley JS, Woloschak G, Grdina DJ, Li JJ. CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection. Free Radic Biol Med. 2015 Apr; 81:77-87.
PMID: 25578653

Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs.
Miller RC, Murley JS, Grdina DJ. Metformin exhibits radiation countermeasures efficacy when used alone or in combination with sulfhydryl containing drugs. Radiat Res. 2014 May; 181(5):464-70.
PMID: 24754562

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John Yuhas Award for Excellence in Research
University of Pennsylvania
1993 - 1993

Japanese Government Research Award for Foreign Specialists
Chiba National Laboratory, Chiba Japan
1988 - 1988